Error detection for genetic data, using likelihood methods.
نویسندگان
چکیده
As genetic maps become denser, the effect of laboratory typing errors becomes more serious. We review a general method for detecting errors in pedigree genotyping data that is a variant of the likelihood-ratio test statistic. It pinpoints individuals and loci with relatively unlikely genotypes. Power and significance studies using Monte Carlo methods are shown by using simulated data with pedigree structures similar to the CEPH pedigrees and a larger experimental pedigree used in the study of idiopathic dilated cardiomyopathy (DCM). The studies show the index detects errors for small values of theta with high power and an acceptable false positive rate. The method was also used to check for errors in DCM laboratory pedigree data and to estimate the error rate in CEPH-chromosome 6 data. The errors flagged by our method in the DCM pedigree were confirmed by the laboratory. The results are consistent with estimated false-positive and false-negative rates obtained using simulation.
منابع مشابه
A New Method for Intrusion Detection Using Genetic Algorithm and Neural network
Abstract— In order to provide complete security in a computer system and to prevent intrusion, intrusion detection systems (IDS) are required to detect if an attacker crosses the firewall, antivirus, and other security devices. Data and options to deal with it. In this paper, we are trying to provide a model for combining types of attacks on public data using combined methods of genetic algorit...
متن کاملA New Method for Intrusion Detection Using Genetic Algorithm and Neural Network
The article attempts to have neural network and genetic algorithm techniques present a model for classification on dataset. The goal is design model can the subject acted a firewall in network and this model with compound optimized algorithms create reliability and accuracy and reduce error rate couse of this is article use feedback neural network and compared to previous methods increase a...
متن کاملA New Method for Intrusion Detection Using Genetic Algorithm and Neural Network
The article attempts to have neural network and genetic algorithm techniques present a model for classification on dataset. The goal is design model can the subject acted a firewall in network and this model with compound optimized algorithms create reliability and accuracy and reduce error rate couse of this is article use feedback neural network and compared to previous methods increase a...
متن کاملDetection of Outliers and Influential Observations in Linear Ridge Measurement Error Models with Stochastic Linear Restrictions
The aim of this paper is to propose some diagnostic methods in linear ridge measurement error models with stochastic linear restrictions using the corrected likelihood. Based on the bias-corrected estimation of model parameters, diagnostic measures are developed to identify outlying and influential observations. In addition, we derive the corrected score test statistic for outliers detection ba...
متن کاملIdentification of outliers types in multivariate time series using genetic algorithm
Multivariate time series data, often, modeled using vector autoregressive moving average (VARMA) model. But presence of outliers can violates the stationary assumption and may lead to wrong modeling, biased estimation of parameters and inaccurate prediction. Thus, detection of these points and how to deal properly with them, especially in relation to modeling and parameter estimation of VARMA m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- American journal of human genetics
دوره 58 1 شماره
صفحات -
تاریخ انتشار 1996